Structural Elucidation of the Mechanistic

Basis of Degeneracy in the Primary Humoral Structural Elucidation of the Mechanistic

ISOLATION AND STRUCTURAL ELUCIDATION OF THE FIRST KNOWN C-HOMOPROTOBERBERINE

A novel C-homoprotoberberine alkaloid, Hediamine (2), has been isolated from the roots of Berberis actinucantha (Berberidaceae). Conclusive proof for the structure of hediamine was obtained by its comparison with the isomeric lactam (4), by chemical transformation, and by means of spectroscopic techniques (UV, IR, MS, NMR).

Structural Overview Of Mammalian Zinc Metalloproteinases

Matrix metalloproteinases (MMP) are crucial for homeostasis (tissue remodelling and repair, bone growth, wound healing, etc.) and pathology (metastasis, angiogenesis, aneurysm rupture, etc.). Upregulated MMPs from macrophages are thus a two-edged sword, playing both defensive and aggressive roles. The related family of ADAMs (a disintegrin and a metalloproteinase) is sometimes overlooked becaus...

Mechanistic-Empirical Analysis of Asphalt Dynamic Modulus for Rehabilitation Projects in Iran

In the Mechanistic–Empirical Pavement Design Guide (MEPDG), dynamic modulus of asphalt mixes is used as one of the input parameters in pavement analysis and design. For in-service pavements, MEPDG method uses a combination of some field and laboratory tests for structural evaluation of asphalt layers in rehabilitation projects. In this study, ten new and rehabilitated in-service asphalt pavemen...

HPLC-SPE-NMR: a productivity tool in natural products research

Natural products provide excellent potential leads for drug development because of their chemical diversity and biological functionality. However, the productivity of discovery of new, pharmacologically active natural products has traditionally been low due to inherent difficulties and costs associated with extract dereplication, i.e., isolation, purification and structure elucidation of indivi...